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dc.contributor.author | Delemarre T. | |
dc.contributor.author | Bochner B.S. | |
dc.contributor.author | Simon H.U. | |
dc.contributor.author | Bachert C. | |
dc.date.accessioned | 2022-02-09T20:32:36Z | |
dc.date.available | 2022-02-09T20:32:36Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0091-6749 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/168883 | |
dc.description.abstract | Chronic rhinosinusitis (CRS) often is characterized by an eosinophilic inflammatory pattern, nowadays referred to as type 2 inflammation, although the mucosal inflammation is dominated by neutrophils in about a third of the patients. Neutrophils are typically predominant in 50% of patients with CRS without nasal polyps, but also are found to play a role in patients with severe type 2 CRS with nasal polyp disease. This review aims at summarizing the current understanding of the eosinophilic and neutrophilic inflammation in CRS pathophysiology, and provides a discussion of their reciprocal interactions and the clinical impact of the mixed presentation in patients with severe type 2 CRS with nasal polyps. A solid understanding of these interactions is of utmost importance when treating uncontrolled severe CRS with nasal polyps with biologicals that are preferentially directed toward type 2 inflammation. We here focus on recent findings on both eosinophilic and neutrophilic granulocytes, their subgroups and the activation status, and their interactions in CRS. | |
dc.relation.ispartofseries | Journal of Allergy and Clinical Immunology | |
dc.subject | activation | |
dc.subject | biologicals | |
dc.subject | Charcot-Leyden crystals | |
dc.subject | Chronic rhinosinusitis | |
dc.subject | eosinophils | |
dc.subject | extracellular traps | |
dc.subject | IL-17 | |
dc.subject | neutrophils | |
dc.subject | type 2 inflammation | |
dc.title | Rethinking neutrophils and eosinophils in chronic rhinosinusitis | |
dc.type | Review | |
dc.relation.ispartofseries-issue | 2 | |
dc.relation.ispartofseries-volume | 148 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 327 | |
dc.source.id | SCOPUS00916749-2021-148-2-SID85111227062 |