dc.contributor.author |
Delemarre T. |
|
dc.contributor.author |
Bochner B.S. |
|
dc.contributor.author |
Simon H.U. |
|
dc.contributor.author |
Bachert C. |
|
dc.date.accessioned |
2022-02-09T20:32:36Z |
|
dc.date.available |
2022-02-09T20:32:36Z |
|
dc.date.issued |
2021 |
|
dc.identifier.issn |
0091-6749 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/168883 |
|
dc.description.abstract |
Chronic rhinosinusitis (CRS) often is characterized by an eosinophilic inflammatory pattern, nowadays referred to as type 2 inflammation, although the mucosal inflammation is dominated by neutrophils in about a third of the patients. Neutrophils are typically predominant in 50% of patients with CRS without nasal polyps, but also are found to play a role in patients with severe type 2 CRS with nasal polyp disease. This review aims at summarizing the current understanding of the eosinophilic and neutrophilic inflammation in CRS pathophysiology, and provides a discussion of their reciprocal interactions and the clinical impact of the mixed presentation in patients with severe type 2 CRS with nasal polyps. A solid understanding of these interactions is of utmost importance when treating uncontrolled severe CRS with nasal polyps with biologicals that are preferentially directed toward type 2 inflammation. We here focus on recent findings on both eosinophilic and neutrophilic granulocytes, their subgroups and the activation status, and their interactions in CRS. |
|
dc.relation.ispartofseries |
Journal of Allergy and Clinical Immunology |
|
dc.subject |
activation |
|
dc.subject |
biologicals |
|
dc.subject |
Charcot-Leyden crystals |
|
dc.subject |
Chronic rhinosinusitis |
|
dc.subject |
eosinophils |
|
dc.subject |
extracellular traps |
|
dc.subject |
IL-17 |
|
dc.subject |
neutrophils |
|
dc.subject |
type 2 inflammation |
|
dc.title |
Rethinking neutrophils and eosinophils in chronic rhinosinusitis |
|
dc.type |
Review |
|
dc.relation.ispartofseries-issue |
2 |
|
dc.relation.ispartofseries-volume |
148 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
327 |
|
dc.source.id |
SCOPUS00916749-2021-148-2-SID85111227062 |
|