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Physcion Enhances Sensitivity of Pancreatic Adenocarcinoma and Lung Carcinoma Cell Lines to Cisplatin

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dc.contributor.author Savenkova D.V.
dc.contributor.author Havrysh V.
dc.contributor.author Skripova V.S.
dc.contributor.author Ionova N.E.
dc.contributor.author Nurgalieva A.K.
dc.contributor.author Minigulova L.F.
dc.contributor.author Bogdanov M.V.
dc.contributor.author Kiyamova R.G.
dc.date.accessioned 2021-02-26T20:49:40Z
dc.date.available 2021-02-26T20:49:40Z
dc.date.issued 2020
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/163231
dc.description.abstract © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Cisplatin is one of the commonly used antitumor drugs for the treatment of different cancers. One of the mechanisms of cisplatin cytotoxicity is associated with oxidative stress initiation. Increased levels of the reactive oxygen species (ROS) are detected in many types of malignancies enhance the cells’ proliferative activity, but its excessively high levels can lead to apoptosis. Thus, one of the promising therapeutic strategies for cancer treatment is the regulation of intracellular ROS levels by targeted drugs. Physcion is an inhibitor of 6PGD enzyme which catalyzes the intracellular antioxidant NADPH formation (Lin et al. in Nature Cell Biology, 17(11), 1484–1496, 2015). In this study, the combined action of the cisplatin and Physcion on the ROS level and viability of human lung (H1299) and pancreatic cancer cell lines (AsPC-1) is described. It was shown that the combined action of Physcion with cisplatin caused a growth in the ROS level in H1299 and AsPC-1 cells up to 1.7 and 2.5 times, respectively, compared with cisplatin alone. Moreover, IC50 of the cisplatin in combination with Physcion decreased up to 1.6 times in the AsPC-1 cells and up to 2.2 times in Н1299 cells compared with cisplatin alone. The enhancing effect of Physcion on cisplatin cytotoxicity is supposedly associated with a ROS balance shift toward increase. Physcion could be considered as an adjunct compound for cancer treatment with DNA-damaging agents.
dc.relation.ispartofseries BioNanoScience
dc.subject Cisplatin
dc.subject Combination therapy
dc.subject Drug sensitivity
dc.subject Lung cancer
dc.subject Pancreatic cancer
dc.subject Physcion
dc.title Physcion Enhances Sensitivity of Pancreatic Adenocarcinoma and Lung Carcinoma Cell Lines to Cisplatin
dc.type Letter
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 549
dc.source.id SCOPUS21911630-2020-10-3-SID85086374243


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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