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Nanostructured polyelectrolyte complexes based on water-soluble thiacalix[4]Arene and pillar[5]arene: Self-assembly in micelleplexes and polyplexes at packaging DNA

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dc.contributor.author Yakimova L.S.
dc.contributor.author Nugmanova A.R.
dc.contributor.author Mostovaya O.A.
dc.contributor.author Vavilova A.A.
dc.contributor.author Shurpik D.N.
dc.contributor.author Mukhametzyanov T.A.
dc.contributor.author Stoikov I.I.
dc.date.accessioned 2021-02-26T20:45:38Z
dc.date.available 2021-02-26T20:45:38Z
dc.date.issued 2020
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/163168
dc.description.abstract © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Controlling the self-assembly of polyfunctional compounds in interpolyelectrolyte aggregates is an extremely challenging task. The use of macrocyclic compounds offers new opportunities in design of a new generation of mixed nanoparticles. This approach allows creating aggregates with multivalent molecular recognition, improved binding effciency and selectivity. In this paper, we reported a straightforward approach to the synthesis of interpolyelectrolytes by co-assembling of the thiacalix[4]arene with four negatively charged functional groups on the one side of macrocycle, and pillar[5]arene with 10 ammonium groups located on both sides. Nanostructured polyelectrolyte complexes show effective packaging of high-molecular DNA from calf thymus. The interaction of co-interpolyelectrolytes with the DNA is completely different from the interaction of the pillar[5]arene with the DNA. Two different complexes with DNA, i.e., micelleplex- and polyplex-type, were formed. The DNA in both cases preserved its secondary structure in native B form without distorting helicity. The presented approach provides important advantage for the design of effective biomolecular gene delivery systems.
dc.subject Co-assembly
dc.subject DNA packing
dc.subject Interpolyelectrolyte
dc.subject Nanomaterials
dc.subject Pillar[5]arene
dc.subject Selective recognition
dc.subject Thiacalix[4]arene
dc.title Nanostructured polyelectrolyte complexes based on water-soluble thiacalix[4]Arene and pillar[5]arene: Self-assembly in micelleplexes and polyplexes at packaging DNA
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2020-10-4-SID85083992609


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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