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The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli

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dc.contributor.author Chernysh I.N.
dc.contributor.author Nagaswami C.
dc.contributor.author Kosolapova S.
dc.contributor.author Peshkova A.D.
dc.contributor.author Cuker A.
dc.contributor.author Cines D.B.
dc.contributor.author Cambor C.L.
dc.contributor.author Litvinov R.I.
dc.contributor.author Weisel J.W.
dc.date.accessioned 2021-02-26T20:45:27Z
dc.date.available 2021-02-26T20:45:27Z
dc.date.issued 2020
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/163163
dc.description.abstract © 2020, The Author(s). Although arterial and venous thromboembolic disorders are among the most frequent causes of mortality and morbidity, there has been little description of how the composition of thrombi and emboli depends on their vascular origin and age. We quantified the structure and composition of arterial and venous thrombi and pulmonary emboli using high-resolution scanning electron microscopy. Arterial thrombi contained a surprisingly large amount of fibrin, in addition to platelets. The composition of pulmonary emboli mirrored the most distal part of venous thrombi from which they originated, which differed from the structure of the body and head of the same thrombi. All thrombi and emboli contained few biconcave red blood cells but many polyhedrocytes or related forms of compressed red blood cells, demonstrating that these structures are a signature of clot contraction in vivo. Polyhedrocytes and intermediate forms comprised the major constituents of venous thrombi and pulmonary emboli. The structures within all of the thrombi and emboli were very tightly packed, in contrast to clots formed in vitro. There are distinctive, reproducible differences among arterial and venous thrombi and emboli related to their origin, destination and duration, which may have clinical implications for the understanding and treatment of thrombotic disorders.
dc.title The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2020-10-1-SID85082092522


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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