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FGB, TNFα, IL-1β, LPL, ITGB3, and TGFB1 genes polymorphism in patients with recurrent myocardial infarction

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dc.contributor.author Mayanskaya Svetlana D.
dc.contributor.author Garaeva Liliya A.
dc.contributor.author Teplyakov Alexandr T.
dc.contributor.author Filipenko Maxim L.
dc.contributor.author Sokolova Ekaterina A.
dc.contributor.author Kravtsova Olga A.
dc.contributor.author Beresikova Ekaterina N.
dc.date.accessioned 2021-02-26T20:40:59Z
dc.date.available 2021-02-26T20:40:59Z
dc.date.issued 2020
dc.identifier.issn 1682-0363
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/163108
dc.description.abstract © 2020 Siberian State Medical University. All rights reserved. The aim. To evaluate the association of fibrinogen (FGB), tumor necrosis factor α (TNFα), interleukin 1β (IL-1β), lipoprotein lipase (LPL), platelet glycoprotein (ITGB3), and transforming growth factor β (TGFB1) genes with the incidence of recurrent myocardial infarction (MI) in patients living in the middle Volga region. Materials and methods. The study included 104 people with recurrent MI compared to 280 people who had just one episode of MI. TNFα (rs1800629), IL1B (rs16944), TGFB1b (rs1800469), FGB (rs1800788), ITGB3 (rs5918) and LPL (rs328) gene polymorphism was determined in all patients using competing TaqMan probes. Association estimation was performed with multivariate logistic regression analysis. Results. Patients with recurrent MI much more often had TNFα, IL1B, TGFB1b, FGB, ITGB3 and LPL allele and genotype polymorphism. Moreover the risk of MI increased significantly in a case of combination of FGB (alleles and genotypes) and TNFα (alleles and genotypes) gene polymorphisms (OR = 4.04, 95% CI = (1.895-8.615), p = 0.0001). Conclusion. Thus, FGB, LPL, TNFα, TGFB1b and ITGB3 gene polymorphism are associated with more severe coronary heart disease and may be a risk factor of recurrent MI development. The dominant total contribution of the FGB (rs1800788) and TNFα (rs1800629) polymorphic genes to the development of recurrent MI in the population of the middle Volga region was revealed.
dc.relation.ispartofseries Bulletin of Siberian Medicine
dc.subject FGB
dc.subject Gene polymorphism
dc.subject IL1B
dc.subject ITGB3
dc.subject LPL
dc.subject Recurrent myocardial infarction
dc.subject TGFB1b
dc.subject TNFα
dc.title FGB, TNFα, IL-1β, LPL, ITGB3, and TGFB1 genes polymorphism in patients with recurrent myocardial infarction
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 19
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 130
dc.source.id SCOPUS16820363-2020-19-4-SID85100502577


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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