Model of an isolated rat heart during readaptation after hypokinesia

Abstract

© 2020, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved. The current study was carried out to evaluate the effect of motor activity (hypokinesia) limitation on the body and organ systems. Hypokinesia contributes to changes in the work of many adaptive systems of the body, which leads to disorders in the musculoskeletal system, respiratory, muscular, and cardiovascular systems. Of particular relevance and practical interest is the effect on the body not only of hypokinesia, but also the processes during the transition from it to an active motor regime (recovery period). The study was carried out on 2 groups of white outbred rats: group 1-animals growing under limited motor activity for 30 days, group 2-animals in the recovery period after 30 days of hypokinesia. The study of the functional parameters of the Langendorff heart of rats (LVP, HR, CF) was carried out on the selected groups. Results of the study revealed that after 30 days of hypokinesia and 14 days recovery period, the heart rate decreased 1.2 times and the coronary flow decreased 2 times. Further, the current study has shown a tendency to restore the heart rate parameters of an isolated heart but the restoration of the coronary flow and cardiac contractility has not been identified. The result of the study suggested that 14 days is not a full-fledged period for the restoration of the functional parameters of the body. This study devoted the effect of motor activity (hypokinesia) limitation on the body and organ systems are relevant and significant.