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Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure

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dc.contributor.author Hollnagel J.O.
dc.contributor.author Cesetti T.
dc.contributor.author Schneider J.
dc.contributor.author Vazetdinova A.
dc.contributor.author Valiullina-Rakhmatullina F.
dc.contributor.author Lewen A.
dc.contributor.author Rozov A.
dc.contributor.author Kann O.
dc.date.accessioned 2021-02-25T20:56:03Z
dc.date.available 2021-02-25T20:56:03Z
dc.date.issued 2020
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162709
dc.description.abstract © 2020 The Author(s) Lactate shuttled from blood, astrocytes, and/or oligodendrocytes may serve as the major glucose alternative in brain energy metabolism. However, its effectiveness in fueling neuronal information processing underlying complex cortex functions like perception and memory is unclear. We show that sole lactate disturbs electrical gamma and theta-gamma oscillations in hippocampal networks by either attenuation or neural bursts. Bursting is suppressed by elevating the glucose fraction in substrate supply. By contrast, lactate does not affect electrical sharp wave-ripple activity featuring lower energy use. Lactate increases the oxygen consumption during the network states, reflecting enhanced oxidative ATP synthesis in mitochondria. Finally, lactate attenuates synaptic transmission in excitatory pyramidal cells and fast-spiking, inhibitory interneurons by reduced neurotransmitter release from presynaptic terminals, whereas action potential generation in the axon is regular. In conclusion, sole lactate is less effective and potentially harmful during gamma-band rhythms by omitting obligatory ATP delivery through fast glycolysis at the synapse.
dc.subject Biochemistry
dc.subject Cell Biology
dc.subject Neuroscience
dc.title Lactate Attenuates Synaptic Transmission and Affects Brain Rhythms Featuring High Energy Expenditure
dc.type Article
dc.relation.ispartofseries-issue 7
dc.relation.ispartofseries-volume 23
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2020-23-7-SID85087691039


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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