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Posttranslational modification of Elongation Factor P from Staphylococcus aureus

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dc.contributor.author Golubev A.
dc.contributor.author Negroni L.
dc.contributor.author Krasnovid F.
dc.contributor.author Validov S.
dc.contributor.author Yusupova G.
dc.contributor.author Yusupov M.
dc.contributor.author Usachev K.
dc.date.accessioned 2021-02-25T20:54:10Z
dc.date.available 2021-02-25T20:54:10Z
dc.date.issued 2020
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162594
dc.description.abstract © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. Antibiotic-resistant Staphylococcus aureus is becoming a major burden on health care systems in many countries, necessitating the identification of new targets for antibiotic development. Elongation Factor P (EF-P) is a highly conserved elongation protein factor that plays an important role in protein synthesis and bacteria virulence. EF-P undergoes unique posttranslational modifications in a stepwise manner to function correctly, but experimental information on EF-P posttranslational modifications is currently lacking for S. aureus. Here, we expressed EF-P in S. aureus to analyze its posttranslational modifications by mass spectrometry and report experimental proof of 5-aminopentanol modification of S. aureus EF-P.
dc.subject EF-P
dc.subject posttranslational modifications
dc.subject ribosome
dc.subject stalling
dc.subject Staphylococcus aureus
dc.title Posttranslational modification of Elongation Factor P from Staphylococcus aureus
dc.type Article
dc.relation.ispartofseries-issue 7
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1342
dc.source.id SCOPUS-2020-10-7-SID85087186292


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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