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Combined supra-and sub-lesional epidural electrical stimulation for restoration of the motor functions after spinal cord injury in mini pigs

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dc.contributor.author Fadeev F.
dc.contributor.author Eremeev A.
dc.contributor.author Bashirov F.
dc.contributor.author Shevchenko R.
dc.contributor.author Izmailov A.
dc.contributor.author Markosyan V.
dc.contributor.author Sokolov M.
dc.contributor.author Kalistratova J.
dc.contributor.author Khalitova A.
dc.contributor.author Garifulin R.
dc.contributor.author Islamov R.
dc.contributor.author Lavrov I.
dc.date.accessioned 2021-02-25T20:52:42Z
dc.date.available 2021-02-25T20:52:42Z
dc.date.issued 2020
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162560
dc.description.abstract © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This study evaluates the effect of combined epidural electrical stimulation (EES) applied above (C5) and below (L2) the spinal cord injury (SCI) at T8–9 combined with motor training on the restoration of sensorimotor function in mini pigs. The motor evoked potentials (MEP) induced by EES applied at C5 and L2 levels were recorded in soleus muscles before and two weeks after SCI. EES treatment started two weeks after SCI and continued for 6 weeks led to improvement in multiple metrics, including behavioral, electrophysiological, and joint kinematics outcomes. In control animals after SCI a multiphasic M-response was observed during M/H-response testing, while animals received EES-enable training demonstrated the restoration of the M-response and H-reflex, although at a lower amplitude. The joint kinematic and assessment with Porcine Thoracic Injury Behavior scale (PTIBS) motor recovery scale demonstrated improvement in animals that received EES-enable training compared to animals with no treatment. The positive effect of two-level (cervical and lumbar) epidural electrical stimulation on functional restoration in mini pigs following spinal cord contusion injury in mini pigs could be related with facilitation of spinal circuitry at both levels and activation of multisegmental coordination. This approach can be taken as a basis for the future development of neuromodulation and neurorehabilitation therapy for patients with spinal cord injury.
dc.subject Epidural electrical stimulation
dc.subject Mini pigs
dc.subject Spinal cord injury
dc.subject Translesional network
dc.title Combined supra-and sub-lesional epidural electrical stimulation for restoration of the motor functions after spinal cord injury in mini pigs
dc.type Article
dc.relation.ispartofseries-issue 10
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1
dc.source.id SCOPUS-2020-10-10-SID85092563625


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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