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Epidural stimulation combined with triple gene therapy for spinal cord injury treatment

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dc.contributor.author Islamov R.
dc.contributor.author Bashirov F.
dc.contributor.author Fadeev F.
dc.contributor.author Shevchenko R.
dc.contributor.author Izmailov A.
dc.contributor.author Markosyan V.
dc.contributor.author Sokolov M.
dc.contributor.author Kuznetsov M.
dc.contributor.author Davleeva M.
dc.contributor.author Garifulin R.
dc.contributor.author Salafutdinov I.
dc.contributor.author Nurullin L.
dc.contributor.author Chelyshev Y.
dc.contributor.author Lavrov I.
dc.date.accessioned 2021-02-25T20:44:40Z
dc.date.available 2021-02-25T20:44:40Z
dc.date.issued 2020
dc.identifier.issn 1661-6596
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162358
dc.description.abstract © 2020 by the authors. Licensee MDPI, Basel, Switzerland. The translation of new therapies for spinal cord injury to clinical trials can be facilitated with large animal models close in morpho-physiological scale to humans. Here, we report functional restoration and morphological reorganization after spinal contusion in pigs, following a combined treatment of locomotor training facilitated with epidural electrical stimulation (EES) and cell-mediated triple gene therapy with umbilical cord blood mononuclear cells overexpressing recombinant vascular endothelial growth factor, glial-derived neurotrophic factor, and neural cell adhesion molecule. Preliminary results obtained on a small sample of pigs 2 months after spinal contusion revealed the difference in post-traumatic spinal cord outcomes in control and treated animals. In treated pigs, motor performance was enabled by EES and the corresponding morpho-functional changes in hind limb skeletal muscles were accompanied by the reorganization of the glial cell, the reaction of stress cell, and synaptic proteins. Our data demonstrate effects of combined EES-facilitated motor training and cell-mediated triple gene therapy after spinal contusion in large animals, informing a background for further animal studies and clinical translation.
dc.relation.ispartofseries International Journal of Molecular Sciences
dc.subject Adenoviral vector
dc.subject Cell-mediated gene therapy
dc.subject Epidural electrical stimulation
dc.subject Glial cell-derived neurotrophic factor
dc.subject Human umbilical cord blood mononuclear cell
dc.subject Neural cell adhesion molecule
dc.subject Pigs
dc.subject Spinal cord injury
dc.subject Vascular endothelial growth factor
dc.title Epidural stimulation combined with triple gene therapy for spinal cord injury treatment
dc.type Article
dc.relation.ispartofseries-issue 23
dc.relation.ispartofseries-volume 21
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1
dc.source.id SCOPUS16616596-2020-21-23-SID85096577277


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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