Synthesis of Water-Soluble Polyammonium Thiacalix[4]arene Derivative and Its Interaction with Calf Thymus DNA

Abstract

© 2020, Pleiades Publishing, Ltd. A water-soluble thiacalix[4]arene derivative containing four diethylenetriamine fragments in 1,3-alternate stereoisomeric form has been obtained for the first time. Using ethidium bromide, it has been found that the macrocycle can interact with calf thymus DNA. The macrocycle has been found to interact with DNA via groove binding. The presence of four diethylenetriamine fragments on the calixarene platform leads to multivalent interactions with DNA, resulting in an increase in the binding constant by two orders of magnitude compared to individual diethylenetriamine.