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Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation

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dc.contributor.author Tang S.
dc.contributor.author Cuellar C.A.
dc.contributor.author Song P.
dc.contributor.author Islam R.
dc.contributor.author Huang C.
dc.contributor.author Wen H.
dc.contributor.author Knudsen B.E.
dc.contributor.author Gong P.
dc.contributor.author Lok U.W.
dc.contributor.author Chen S.
dc.contributor.author Lavrov I.A.
dc.date.accessioned 2021-02-25T20:37:06Z
dc.date.available 2021-02-25T20:37:06Z
dc.date.issued 2020
dc.identifier.issn 1053-8119
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/162039
dc.description.abstract © 2020 The Authors In this study functional ultrasound (fUS) imaging has been implemented to explore the local hemodynamics response induced by electrical epidural stimulation and to study real-time in vivo functional changes of the spinal cord, taking advantage of the superior spatiotemporal resolution provided by fUS. By quantifying the hemodynamics and electromyographic response features, we tested the hypothesis that the temporal hemodynamics response of the spinal cord to electrical epidural stimulation could reflect modulation of the spinal circuitry and accordingly respond to the changes in parameters of electrical stimulation. The results of this study for the first time demonstrate that the hemodynamics response to electrical stimulation could reflect a neural-vascular coupling of the spinal cord. Response in the dorsal areas to epidural stimulation was significantly higher and faster compared to the response in ventral spinal cord. Positive relation between the hemodynamics and the EMG responses was observed at the lower frequencies of epidural stimulation (20 and 40 Hz), which according to our previous findings can facilitate spinal circuitry after spinal cord injury, compared to higher frequencies (200 and 500 Hz). These findings suggest that different mechanisms could be involved in spinal cord hemodynamics changes during different parameters of electrical stimulation and for the first time provide the evidence that neural-vascular coupling of the spinal cord circuitry could be related to specific organization of spinal cord vasculature and hemodynamics.
dc.relation.ispartofseries NeuroImage
dc.subject Epidural electrical stimulation
dc.subject Functional ultrasound
dc.subject Hemodynamics responses
dc.subject Spinal cord
dc.title Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation
dc.type Article
dc.relation.ispartofseries-volume 221
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS10538119-2020-221-SID85088790240


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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