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dc.contributor.author | Muguruma K. | |
dc.contributor.author | Pradipta A.R. | |
dc.contributor.author | Ode Y. | |
dc.contributor.author | Terashima K. | |
dc.contributor.author | Michiba H. | |
dc.contributor.author | Fujii M. | |
dc.contributor.author | Tanaka K. | |
dc.date.accessioned | 2021-02-25T20:35:59Z | |
dc.date.available | 2021-02-25T20:35:59Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/161957 | |
dc.description.abstract | © 2020 Elsevier Ltd Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy. | |
dc.relation.ispartofseries | Bioorganic and Medicinal Chemistry | |
dc.subject | Acrolein | |
dc.subject | Diagnosis | |
dc.subject | Disease-associated substrate | |
dc.subject | In vivo synthetic chemistry | |
dc.subject | Therapy | |
dc.title | Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 24 | |
dc.relation.ispartofseries-volume | 28 | |
dc.collection | Публикации сотрудников КФУ | |
dc.source.id | SCOPUS09680896-2020-28-24-SID85096168498 |