dc.contributor.author |
Muguruma K. |
|
dc.contributor.author |
Pradipta A.R. |
|
dc.contributor.author |
Ode Y. |
|
dc.contributor.author |
Terashima K. |
|
dc.contributor.author |
Michiba H. |
|
dc.contributor.author |
Fujii M. |
|
dc.contributor.author |
Tanaka K. |
|
dc.date.accessioned |
2021-02-25T20:35:59Z |
|
dc.date.available |
2021-02-25T20:35:59Z |
|
dc.date.issued |
2020 |
|
dc.identifier.issn |
0968-0896 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/161957 |
|
dc.description.abstract |
© 2020 Elsevier Ltd Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy. |
|
dc.relation.ispartofseries |
Bioorganic and Medicinal Chemistry |
|
dc.subject |
Acrolein |
|
dc.subject |
Diagnosis |
|
dc.subject |
Disease-associated substrate |
|
dc.subject |
In vivo synthetic chemistry |
|
dc.subject |
Therapy |
|
dc.title |
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
24 |
|
dc.relation.ispartofseries-volume |
28 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.source.id |
SCOPUS09680896-2020-28-24-SID85096168498 |
|