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Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry

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dc.contributor.author Muguruma K.
dc.contributor.author Pradipta A.R.
dc.contributor.author Ode Y.
dc.contributor.author Terashima K.
dc.contributor.author Michiba H.
dc.contributor.author Fujii M.
dc.contributor.author Tanaka K.
dc.date.accessioned 2021-02-25T20:35:59Z
dc.date.available 2021-02-25T20:35:59Z
dc.date.issued 2020
dc.identifier.issn 0968-0896
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161957
dc.description.abstract © 2020 Elsevier Ltd Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
dc.relation.ispartofseries Bioorganic and Medicinal Chemistry
dc.subject Acrolein
dc.subject Diagnosis
dc.subject Disease-associated substrate
dc.subject In vivo synthetic chemistry
dc.subject Therapy
dc.title Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry
dc.type Article
dc.relation.ispartofseries-issue 24
dc.relation.ispartofseries-volume 28
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS09680896-2020-28-24-SID85096168498


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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