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Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin

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dc.contributor.author Montgomery S.A.
dc.contributor.author Tanizawa Y.
dc.contributor.author Galik B.
dc.contributor.author Wang N.
dc.contributor.author Ito T.
dc.contributor.author Mochizuki T.
dc.contributor.author Akimcheva S.
dc.contributor.author Bowman J.L.
dc.contributor.author Cognat V.
dc.contributor.author Maréchal-Drouard L.
dc.contributor.author Ekker H.
dc.contributor.author Hong S.F.
dc.contributor.author Kohchi T.
dc.contributor.author Lin S.S.
dc.contributor.author Liu L.Y.D.
dc.contributor.author Nakamura Y.
dc.contributor.author Valeeva L.R.
dc.contributor.author Shakirov E.V.
dc.contributor.author Shippen D.E.
dc.contributor.author Wei W.L.
dc.contributor.author Yagura M.
dc.contributor.author Yamaoka S.
dc.contributor.author Yamato K.T.
dc.contributor.author Liu C.
dc.contributor.author Berger F.
dc.date.accessioned 2021-02-25T20:35:54Z
dc.date.available 2021-02-25T20:35:54Z
dc.date.issued 2020
dc.identifier.issn 0960-9822
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161946
dc.description.abstract © 2019 Genome packaging by nucleosomes is a hallmark of eukaryotes. Histones and the pathways that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack information regarding chromatin landscapes in extant representatives of ancestors of the main groups of eukaryotes, and our knowledge of the evolution of chromatin-related processes is limited. We used the bryophyte Marchantia polymorpha, which diverged from vascular plants circa 400 mya, to obtain a whole chromosome genome assembly and explore the chromatin landscape and three-dimensional genome organization in an early diverging land plant lineage. Based on genomic profiles of ten chromatin marks, we conclude that the relationship between active marks and gene expression is conserved across land plants. In contrast, we observed distinctive features of transposons and other repetitive sequences in Marchantia compared with flowering plants. Silenced transposons and repeats did not accumulate around centromeres. Although a large fraction of constitutive heterochromatin was marked by H3K9 methylation as in flowering plants, a significant proportion of transposons were marked by H3K27me3, which is otherwise dedicated to the transcriptional repression of protein-coding genes in flowering plants. Chromatin compartmentalization analyses of Hi-C data revealed that repressed B compartments were densely decorated with H3K27me3 but not H3K9 or DNA methylation as reported in flowering plants. We conclude that, in early plants, H3K27me3 played an essential role in heterochromatin function, suggesting an ancestral role of this mark in transposon silencing. Montgomery et al. provide a chromosome-scale genome assembly of the early diverging land plant Marchantia polymorpha. Profiling of chromatin marks shows conserved roles of active marks and suggests an ancestral association between H3K27me3 and transposons that is partly retained in Marchantia and replaced by H3K9 methylation in flowering plants.
dc.relation.ispartofseries Current Biology
dc.subject bryophytes
dc.subject chromatin
dc.subject evolution
dc.subject genome
dc.subject H3K27me3
dc.subject Marchantia
dc.subject sex chromosome
dc.subject transposon
dc.title Chromatin Organization in Early Land Plants Reveals an Ancestral Association between H3K27me3, Transposons, and Constitutive Heterochromatin
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 30
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 573
dc.source.id SCOPUS09609822-2020-30-4-SID85079523320


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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