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Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells

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dc.contributor.author Andrianov V.V.
dc.contributor.author Yafarova G.G.
dc.contributor.author Pashkevich S.G.
dc.contributor.author Tokalchik Y.P.
dc.contributor.author Dosina M.O.
dc.contributor.author Zamaro A.S.
dc.contributor.author Bogodvid T.K.
dc.contributor.author Iyudin V.S.
dc.contributor.author Bazan L.V.
dc.contributor.author Kulchitsky V.A.
dc.contributor.author Gainutdinov K.L.
dc.date.accessioned 2021-02-25T20:35:41Z
dc.date.available 2021-02-25T20:35:41Z
dc.date.issued 2020
dc.identifier.issn 0937-9347
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161928
dc.description.abstract © 2020, Springer-Verlag GmbH Austria, part of Springer Nature. A comparative experimental analysis by EPR spectroscopy of the intensity of nitric oxide (NO) production and the content of the copper in the tissues of olfactory bulb of the brain of male Wistar rats were performed after modeling of ischemic stroke and treatment with immediate intranasal injection of mesenchymal stem cells (MSCs). Brain ischemia was simulated by ligation at the level of bifurcation of the common carotid arteries. It was found a significant reduction of NO content in the olfactory bulb of the brain of rats on the 1st and 2nd days after modeling of ischemia. The level of NO production was also reduced on the 1st and 2nd days after ischemia with MSCs’ administration as compared to intact animals. It was not found the significant difference of the NO content in rats after ischemia with MSCs’ administration relative to ischemic rats. The copper content in the olfactory bulb of the rat, which corresponds to the level of superoxide dismutase 1 and 3, tended to increase after modeling ischemia and remained for 2 days. The MSCs’ administration was accompanied by a significant increase in copper content on the 1st day after modeling of ischemia and by decrease of its content on 2nd day after ischemia. The experiments showed that MSCs’ administration did not affect the intensity of NO production on the 1st and 2nd days after the modeling of brain ischemia, but was accompanied by an increase in the antioxidant protection of the nervous tissue 1 day after ischemia.
dc.relation.ispartofseries Applied Magnetic Resonance
dc.title Changes of the Nitric Oxide and Copper Content in the Olfactory Bulbs of Rat Brain After Modeling of Brain Stroke and Intranasal Administration of Mesenchymal Stem Cells
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 51
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 375
dc.source.id SCOPUS09379347-2020-51-4-SID85081202239


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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