Extraction of aromatic abietane diterpenoids from Salvia officinalis leaves by petroleum ether: Data resolution analysis

Abstract

© 2019 Elsevier B.V. Salvia officinalis is the source of a vast variety of compounds valuable for pharmaceutical and food industry. The extractability of lipophilic diterpenoids from S. officinalis(L.) by petroleum ether is studied using Soxhlet, reflux, and percolation methods. The binding of the solute to the plant matrix is described by the Hill-Langmuir desorption model. The Monte Carlo sampling method is used to constrain the parameters of the extraction model and perform the resolution analysis of the extraction data. The percolation, followed by extraction at reflux, is demonstrated to be the most efficient method of extraction. The freely available content is estimated to be ye = 20.0 ± 2.9 mg g–1, while the total content in our case is shown to be 50–55 mg g–1 or higher. For engineering applications, the estimate of 60–70 mg g–1 is suggested as the upper limit.