Show simple item record Boulygina E.A. Borisov O.V. Valeeva E.V. Semenova E.A. Kostryukova E.S. Kulemin N.A. Larin A.K. Nabiullina R.M. Mavliev F.A. Akhatov A.M. Andryushchenko O.N. Andryushchenko L.B. Zmijewski P. Generozov E.V. Ahmetov I.I. 2021-02-25T20:35:20Z 2021-02-25T20:35:20Z 2020
dc.identifier.issn 0860-021X
dc.description.abstract © 2020 Institute of Sport. All rights reserved. Whole genome sequencing (WGS) has great potential to explore all possible DNA variants associated with physical performance, psychological traits and health conditions of athletes. Here we present, for the first time, annotation of genomic variants of elite athletes, based on the WGS of 20 Tatar male wrestlers. The maximum number of high-quality variants per sample was over 3.8 M for single nucleotide polymorphisms (SNPs) and about 0.64 M for indels. The maximum number of nonsense mutations was 148 single nucleotide variants (SNVs) per individual. Athletes' genomes on average contained 18.9 nonsense SNPs in a homozygous state per sample, while non-Athletes' exomes (Tatar controls, n = 19) contained 18 nonsense SNPs. Finally, we applied genomic data for the association analysis and used reaction time (RT) as an example. Out of 1884 known genome-wide significant SNPs related to RT, we identified four SNPs (KIF27 rs10125715, APC rs518013, TMEM229A rs7783359, LRRN3 rs80054135) associated with RT in wrestlers. The cumulative number of favourable alleles (KIF27 A, APC A, TMEM229A T, LRRN3 T) was significantly correlated with RT both in wrestlers (P = 0.0003) and an independent cohort (n = 43) of physically active subjects (P = 0.029). Furthermore, we found that the frequencies of the APC A (53.3 vs 44.0%, P = 0.033) and LRRN3 T (7.5 vs 2.8%, P = 0.009) alleles were significantly higher in elite athletes (n = 107) involved in sports with RT as an essential component of performance (combat sports, table tennis and volleyball) compared to less successful (n = 176) athletes. The LRRN3 T allele was also over-represented in elite athletes (7.5%) in comparison with 189 controls (2.9%, P = 0.009). In conclusion, we present the first WGS study of athletes showing that WGS can be applied in sport and exercise science.
dc.relation.ispartofseries Biology of Sport
dc.subject Athletic performance
dc.subject Genotype
dc.subject Polymorphism
dc.subject Reaction time
dc.subject Wrestling
dc.title Whole genome sequencing of elite athletes
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 37
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 295 SCOPUS0860021X-2020-37-3-SID85090065081

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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