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Kinetic stability of amorphous dipyridamole: A fast scanning calorimetry investigation

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dc.contributor.author Lapuk S.E.
dc.contributor.author Mukhametzyanov T.A.
dc.contributor.author Schick C.
dc.contributor.author Gerasimov A.V.
dc.date.accessioned 2021-02-25T20:35:07Z
dc.date.available 2021-02-25T20:35:07Z
dc.date.issued 2020
dc.identifier.issn 0378-5173
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161867
dc.description.abstract © 2019 Elsevier B.V. One of the main tasks of modern pharmaceutics is enhancing the solubility of drugs. The approaches for solving this problem include producing active pharmaceutical ingredients in the amorphous state. However, the use of amorphous drugs requires the determination of their kinetic stability. The latter is often assessed using isothermal techniques, which are time-consuming. Alternatively, non-isothermal methods can be employed, allowing to determine the kinetic triplet more rapidly. Also, such techniques can be used to develop predictive models for storage stability. The production of the amorphous state itself typically requires fast cooling rates, which may not be easily accessible. Fast scanning calorimetry is a promising tool for the investigation of amorphous drug systems. In the present work, the crystallization of the model drug dipyridamole was investigated using the fast scanning calorimetry method. The kinetic stability of the amorphous form of the drug was evaluated using both, isothermal and non-isothermal methods. The Nakamura crystallization model was found to be applicable for the prediction of the temporal stability of the amorphous drug forms. The obtained results may find applications in the investigation of the kinetic stability of amorphous drug systems.
dc.relation.ispartofseries International Journal of Pharmaceutics
dc.subject Calorimetry
dc.subject Crystallization
dc.subject Drug
dc.subject Glass
dc.subject Kinetics
dc.subject Stability
dc.subject Thermal analysis
dc.title Kinetic stability of amorphous dipyridamole: A fast scanning calorimetry investigation
dc.type Article
dc.relation.ispartofseries-volume 574
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS03785173-2020-574-SID85076036462

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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