Kazan Federal University Digital Repository

In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines

Show simple item record

dc.contributor.author Abdul-Hafeez E.Y.
dc.contributor.author Orabi M.A.A.
dc.contributor.author Ibrahim O.H.M.
dc.contributor.author Ilinskaya O.
dc.contributor.author Karamova N.S.
dc.date.accessioned 2021-02-25T20:34:43Z
dc.date.available 2021-02-25T20:34:43Z
dc.date.issued 2020
dc.identifier.issn 0254-6299
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161815
dc.description.abstract © 2020 SAAB Among the plants which are determined to be a promising source of anticarcenogenic agents are members of Agavaceae family which are common in tropical and subtropical regions such as Egypt. In this study, cytotoxic activity were assessed for the methanolic extracts and fractions from five members of Agavaceae family: Sansevieria cylindrica Bojer., Polianthes tuberosa L., Sansevieria trifasciata Prain., Yucca filamentosa L. and Furcraea watsoniana Hort. against MCF-7 (breast), HepG-2 (hepatoma), and Caco-2 (colon) cancer cell lines by MTT method. The n-hexane fraction of P. tuberosa leaves extract demonstrated strong cytotoxic potential against all three cancer cell lines (CC50<20 µg/ml). The ethyl acetate fractions of Y. filamentosa and F. watsoniana leaves significantly inhibited proliferation of hepatocellular HepG-2 (CC50 = 6.21 µg/ml and 19.07 µg/ml, respectively) and intestinal epithelium Caco-2 carcinoma cells (CC50 = 18.86 µg/ml and 23.25 µg/ml, respectively). Presumably, the cytotoxic activity exhibited by n-hexane fraction of P. tuberosa, ethyl acetate fractions of Y. filamentosa and F. watsoniana may be related to the steroidal saponins that are present in these samples.
dc.relation.ispartofseries South African Journal of Botany
dc.subject Agavaceae family
dc.subject Caco-2
dc.subject Cytotoxicity
dc.subject HepG-2
dc.subject MCF-7
dc.subject Steroidal saponins
dc.title In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines
dc.type Article
dc.relation.ispartofseries-volume 131
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 295
dc.source.id SCOPUS02546299-2020-131-SID85081662820


Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace


Advanced Search

Browse

My Account