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Early ultra- and microstructural alterations in rat pancreas in alloxan-induced diabetes mellitus

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dc.contributor.author Titova A.A.
dc.contributor.author Mavlikeev M.O.
dc.contributor.author Kaligin M.S.
dc.contributor.author Suleymanova D.M.
dc.contributor.author Chekmaryeva I.A.
dc.contributor.author Kiyasov A.P.
dc.contributor.author Deev R.V.
dc.date.accessioned 2021-02-25T20:34:26Z
dc.date.available 2021-02-25T20:34:26Z
dc.date.issued 2020
dc.identifier.issn 0191-3123
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161783
dc.description.abstract © 2019, © 2019 Taylor & Francis Group, LLC. An adequate experimental model is important to understand pathophysiological processes ongoing in the pancreas with diabetes mellitus. Our study was aimed to describe early ultra- and microstructural changes in the rat pancreas in 12–48 h after alloxan administration in a dose of 180 mg/kg. A histopathological examination of the endocrine pancreas revealed the loss of borders between endocrine cells, granular dystrophy and degranulation, sings of necrosis in central cells of the Langerhans islets and apoptosis of their peripheral ones manifested as DNA fragmentation and an increased expression of apoptosis markers. There was a gradual increase of a Langerhans islet area, a decreased percentage of insulin+ cells and an increased one of glucagon+ cells, as well as the presence of proliferating islet cells were found. Structural changes of the exocrine pancreas included fatty degeneration, signs of exocrine cell mitochondrial damage, increased acini, which are located mainly around the Langerhans islets, as well as perivascular edema and leukocytic infiltration. Described ultra- and microstructural alterations suggest a significant contribution of apoptosis to death of endocrine cells exposed to alloxan. Coexisting damage of the exocrine pancreas with its stroma involvement is for the first time described.
dc.relation.ispartofseries Ultrastructural Pathology
dc.subject alloxan
dc.subject diabetes mellitus
dc.subject Langerhans islet
dc.subject α-cells
dc.subject β-cells
dc.title Early ultra- and microstructural alterations in rat pancreas in alloxan-induced diabetes mellitus
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 44
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 61
dc.source.id SCOPUS01913123-2020-44-1-SID85077887733


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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