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Oral Ciprofloxacin Pharmacokinetics in Healthy Mexican Volunteers and Other Populations: Is There Interethnic Variability?

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dc.contributor.author Tolentino-Hernández S.J.
dc.contributor.author Cruz-Antonio L.
dc.contributor.author Pérez-Urizar J.
dc.contributor.author Cabrera-Fuentes H.A.
dc.contributor.author Castañeda-Hernández G.
dc.date.accessioned 2021-02-25T20:34:25Z
dc.date.available 2021-02-25T20:34:25Z
dc.date.issued 2020
dc.identifier.issn 0188-4409
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161782
dc.description.abstract © 2020 IMSS Background: There is evidence that the pharmacokinetics of certain drugs in Mexicans may differ with respect to other ethnic groups. On the other hand, there is controversy about the existence of interethnic variability in the pharmacokinetics of ciprofloxacin. Aim of the study: To study oral ciprofloxacin pharmacokinetics in Mexicans at various dose levels and make comparisons with other populations in order to gain insight on interethnic variability. Methods: Healthy Mexican volunteers received oral ciprofloxacin as 250 mg and 500 mg immediate-release tablets or a 1,000 mg extended-release formulation. Plasma concentration against time curves were constructed, and pharmacokinetic parameters were compared with those reported for other populations. Results: Ciprofloxacin pharmacokinetics in Mexicans was linear and no significant differences between males and females were detected. When several populations were compared, it appeared that bioavailability in Mexicans was similar to that of Caucasians, being lower than that of Asians. These variations were attenuated when data were normalized by body weight. Conclusions: Ciprofloxacin pharmacokinetics exhibit interethnic variability, Asians exhibiting an increased bioavailability with regard to Mexicans and Caucasians. Data suggest that these differences are due to body weight.
dc.relation.ispartofseries Archives of Medical Research
dc.subject Ciprofloxacin
dc.subject Ethnic groups
dc.subject Interethnic variability
dc.subject Pharmacokinetics
dc.title Oral Ciprofloxacin Pharmacokinetics in Healthy Mexican Volunteers and Other Populations: Is There Interethnic Variability?
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 51
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 268
dc.source.id SCOPUS01884409-2020-51-3-SID85081341959

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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