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NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus

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dc.contributor.author Golubev A.
dc.contributor.author Fatkhullin B.
dc.contributor.author Gabdulkhakov A.
dc.contributor.author Bikmullin A.
dc.contributor.author Nurullina L.
dc.contributor.author Garaeva N.
dc.contributor.author Islamov D.
dc.contributor.author Klochkova E.
dc.contributor.author Klochkov V.
dc.contributor.author Aganov A.
dc.contributor.author Khusainov I.
dc.contributor.author Validov S.
dc.contributor.author Yusupova G.
dc.contributor.author Yusupov M.
dc.contributor.author Usachev K.
dc.date.accessioned 2021-02-25T20:34:25Z
dc.date.available 2021-02-25T20:34:25Z
dc.date.issued 2020
dc.identifier.issn 0175-7571
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161781
dc.description.abstract © 2020, European Biophysical Societies' Association. Elongation factor P (EF-P) is a translation protein factor that plays an important role in specialized translation of consecutive proline amino acid motifs. EF-P is an essential protein for cell fitness in native environmental conditions. It regulates synthesis of proteins involved in bacterial motility, environmental adaptation and bacterial virulence, thus making EF-P a potential drug target. In the present study, we determined the solution and crystal structure of EF-P from the pathogenic bacteria Staphylococcus aureus at 1.48 Å resolution. The structure can serve as a platform for structure-based drug design of novel antibiotics to combat the growing antibiotic resistance of S. aureus.
dc.relation.ispartofseries European Biophysics Journal
dc.subject Drug target
dc.subject EF-P
dc.subject NMR
dc.subject Protein structure
dc.subject Ribosome
dc.subject Staphylococcus aureus
dc.subject X-ray
dc.title NMR and crystallographic structural studies of the Elongation factor P from Staphylococcus aureus
dc.type Article
dc.relation.ispartofseries-issue 3-4
dc.relation.ispartofseries-volume 49
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 223
dc.source.id SCOPUS01757571-2020-49-34-SID85081284888

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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