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Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1

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dc.contributor.author Shah Mahmud R.
dc.contributor.author Efimova M.A.
dc.contributor.author Ulyanova V.
dc.contributor.author Ravilov R.K.
dc.contributor.author Shuralev E.A.
dc.contributor.author Kolpakov A.
dc.contributor.author Ilinskaya O.
dc.date.accessioned 2021-02-25T20:34:04Z
dc.date.available 2021-02-25T20:34:04Z
dc.date.issued 2020
dc.identifier.issn 0168-1702
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161773
dc.description.abstract © 2020 Elsevier B.V. Reoviruses (respiratory enteric orphan viruses) are nonenveloped viruses with segmented dsRNA genome. Viruses in the family Reoviridae are quite stable in the environment. Recently, they have been identified with various pathologies and physiologic dysfunctions in a wide range of organs and tissues, including the hepatobiliary system, the myocardium, lungs, and endocrine tissues. Although most cases of reovirus infection are mild or subclinical diseases, the prevention measures are currently needed, especially for young children suffering from dehydrating gastroenteritis. To inhibit viral replication, different RNases targeting viral RNA are proposed. Here, we first have shown that RNase from Bacillus pumilus (binase) acts as an antiviral agent at the level of the whole animal organism infected by Mammalian orthoreovirus 1 strain Lang (TL1). The results obtained on the mice model infected with 10 LD50 and 20 LD50 doses of reovirus indicate the restoration of mice physiological parameters under binase treatment at the dose of 50 μg/mouse. Thus, our research supports the relevance of binase as a promising antiviral agent that affects viral RNA.
dc.relation.ispartofseries Virus Research
dc.subject Antiviral
dc.subject Binase
dc.subject Mice infection
dc.subject Reovirus serotype 1
dc.subject Ribonuclease
dc.subject Strain Lang
dc.title Bacillus pumilus ribonuclease rescues mice infected by double-stranded RNA-containing reovirus serotype 1
dc.type Article
dc.relation.ispartofseries-volume 286
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS01681702-2020-286-SID85087749764

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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