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Structural details on the interaction of biologically active sulfur-containing monoterpenoids with lipid membranes

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dc.contributor.author Nikitina L.
dc.contributor.author Pavelyev R.
dc.contributor.author Startseva V.
dc.contributor.author Kiselev S.
dc.contributor.author Galiullina L.
dc.contributor.author Aganova O.
dc.contributor.author Timerova A.
dc.contributor.author Boichuk S.
dc.contributor.author Azizova Z.
dc.contributor.author Klochkov V.
dc.contributor.author Huster D.
dc.contributor.author Khodov I.
dc.contributor.author Scheidt H.
dc.date.accessioned 2021-02-25T20:33:57Z
dc.date.available 2021-02-25T20:33:57Z
dc.date.issued 2020
dc.identifier.issn 0167-7322
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161756
dc.description.abstract © 2019 Elsevier B.V. In this work, we propose the synthesis of new thioterpenoids of a bornane series and study the influence of these compounds on hemostasis. The results from this study suggest that among all investigated terpenoids, sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetate may be the most promising for further development due to enhanced inhibition of the spontaneous aggregation compared with isoborneol, and because of its higher solubility in water compared with ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetic acid, which has approximately the same antiaggregatory and anticoagulant properties. In accordance with one hypothesis, the distribution of the studied bioactive molecules within the cellular lipid membrane can directly influence the anticoagulant properties. In the current work, the interactions of thioterpenoids with phospholipid membranes have been studied using various NMR techniques. The findings of this study indicate that sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetateexhibits a membrane location, which is shifted somewhat in the direction of the lipid-water interface. Such a location may shield the compound from interactions with hydrophobic lipid segments. In contrast, isoborneol is more deeply immersed in the membrane. These results represent an initial step toward developing new drugs based on the synthesized thioterpenoids in order to increase the effectiveness of treatment and prevention of several human diseases accompanying disorders in the hemostasis system.
dc.relation.ispartofseries Journal of Molecular Liquids
dc.subject 1D and 2D solution-state NMR
dc.subject Coagulation activity
dc.subject DOSY
dc.subject Isoborneol
dc.subject Model cell membranes
dc.subject Molecular mechanism of coagulation activity
dc.subject NOESY
dc.subject Platelets aggregation
dc.subject Solid-state NMR
dc.subject Thioterpenoids
dc.title Structural details on the interaction of biologically active sulfur-containing monoterpenoids with lipid membranes
dc.type Article
dc.relation.ispartofseries-volume 301
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS01677322-2020-301-SID85077509815

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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