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Effects of Homocysteine and its Derivatives on Spontaneous Network Activity in the Hippocampus of Neonatal Rat Pups

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dc.contributor.author Kurmashova E.D.
dc.contributor.author Gataulina E.D.
dc.contributor.author Zefirov A.L.
dc.contributor.author Sitdikova G.F.
dc.contributor.author Yakovlev A.V.
dc.date.accessioned 2021-02-25T20:33:48Z
dc.date.available 2021-02-25T20:33:48Z
dc.date.issued 2020
dc.identifier.issn 0097-0549
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161738
dc.description.abstract © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Homocysteine is a sulfur-containing amino acid, which at high concentrations has neurotoxic effects and induces impairments to the development of the nervous system. Homocysteine is rapidly oxidized in the plasma, forming disulfide bonds with proteins and other low molecular weight thiols; it also undergoes transformation into the into homocysteine thiolactone. On chronic exposure, the neurotoxicity of homocysteine is therefore mediated mainly by its derivatives. The aim of the present work was to investigate the effects of homocysteine and its derivatives – homocystine and homocysteine thiolactone – on spontaneous network activity in the hippocampus of rats in the first week after birth. Giant depolarizing potentials (GDP) and multiple action potentials (MAP) were recorded using an extracellular electrode in hippocampal field CA3. All three study compounds were found to induce increases in the frequency of GDP and MAP at concentrations of 100 and 500 μM, homocystine producing the most significant increase in neuron network activity. The effects of homocysteine, homocystine, and homocysteine thiolactone on the spontaneous network activity of neurons were completely eliminated on blockade of NMDA and AMPA receptors. Thus, homocysteine and its derivatives lead to increased spontaneous network activity of hippocampal neurons in neonatal rats, which can induce impairments to the formation of the neural networks of the hippocampus in conditions of chronic hyperhomocysteinemia, and could also induce hyperexcitability and the risk of developing epilepsy in the postnatal period.
dc.relation.ispartofseries Neuroscience and Behavioral Physiology
dc.subject AMPA receptors
dc.subject giant depolarizing potentials
dc.subject hippocampus
dc.subject homocysteine
dc.subject homocysteine thiolactone
dc.subject homocystine
dc.subject NMDA receptors
dc.title Effects of Homocysteine and its Derivatives on Spontaneous Network Activity in the Hippocampus of Neonatal Rat Pups
dc.type Article
dc.relation.ispartofseries-issue 7
dc.relation.ispartofseries-volume 50
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 907
dc.source.id SCOPUS00970549-2020-50-7-SID85092229199


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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