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Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors

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dc.contributor.author Padnya P.L.
dc.contributor.author Bayarashov E.E.
dc.contributor.author Zueva I.V.
dc.contributor.author Lushchekina S.V.
dc.contributor.author Lenina O.A.
dc.contributor.author Evtugyn V.G.
dc.contributor.author Osin Y.N.
dc.contributor.author Petrov K.A.
dc.contributor.author Stoikov I.I.
dc.date.accessioned 2021-02-25T20:33:26Z
dc.date.available 2021-02-25T20:33:26Z
dc.date.issued 2020
dc.identifier.issn 0045-2068
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/161719
dc.description.abstract © 2019 Elsevier Inc. Novel ammonium and betaine derivatives of p-tert-butylthiacalix[4]arene in cone and 1,3-alternate conformation were synthesized with high yields for the first time. The obtained compounds form in water spherical nanoparticles. It was shown by molecular docking calculations and in vitro experiments that amino and betaine derivatives can inhibit acetylcholinesterase and butyrylcholinesterase on the level of pyridostigmine while the toxicity of the obtained compounds is much lower than that of pyridostigmine.
dc.relation.ispartofseries Bioorganic Chemistry
dc.subject Amines
dc.subject Betaines
dc.subject Biological activity
dc.subject Cholinesterase inhibitors
dc.subject Thiacalixarenes
dc.title Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors
dc.type Article
dc.relation.ispartofseries-volume 94
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS00452068-2020-94-SID85075925503


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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