Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors

dc.contributor.author	Padnya P.L.
dc.contributor.author	Bayarashov E.E.
dc.contributor.author	Zueva I.V.
dc.contributor.author	Lushchekina S.V.
dc.contributor.author	Lenina O.A.
dc.contributor.author	Evtugyn V.G.
dc.contributor.author	Osin Y.N.
dc.contributor.author	Petrov K.A.
dc.contributor.author	Stoikov I.I.
dc.date.accessioned	2021-02-25T20:33:26Z
dc.date.available	2021-02-25T20:33:26Z
dc.date.issued	2020
dc.identifier.issn	0045-2068
dc.identifier.uri	https://dspace.kpfu.ru/xmlui/handle/net/161719
dc.description.abstract	© 2019 Elsevier Inc. Novel ammonium and betaine derivatives of p-tert-butylthiacalix[4]arene in cone and 1,3-alternate conformation were synthesized with high yields for the first time. The obtained compounds form in water spherical nanoparticles. It was shown by molecular docking calculations and in vitro experiments that amino and betaine derivatives can inhibit acetylcholinesterase and butyrylcholinesterase on the level of pyridostigmine while the toxicity of the obtained compounds is much lower than that of pyridostigmine.
dc.relation.ispartofseries	Bioorganic Chemistry
dc.subject	Amines
dc.subject	Betaines
dc.subject	Biological activity
dc.subject	Cholinesterase inhibitors
dc.subject	Thiacalixarenes
dc.title	Water-soluble betaines and amines based on thiacalix[4]arene scaffold as new cholinesterase inhibitors
dc.type	Article
dc.relation.ispartofseries-volume	94
dc.collection	Публикации сотрудников КФУ
dc.source.id	SCOPUS00452068-2020-94-SID85075925503

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Публикации сотрудников КФУ Scopus [24551]
Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.