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The State of the Nitric Oxide Cycle in Respiratory Tract Diseases

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dc.contributor.author Soodaeva S.
dc.contributor.author Klimanov I.
dc.contributor.author Kubysheva N.
dc.contributor.author Popova N.
dc.contributor.author Batyrshin I.
dc.date.accessioned 2021-02-25T06:40:15Z
dc.date.available 2021-02-25T06:40:15Z
dc.date.issued 2020
dc.identifier.issn 1942-0900
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160968
dc.description.abstract © 2020 Svetlana Soodaeva et al. This review describes the unique links of the functioning of the nitric oxide cycle in the respiratory tract in normal and pathological conditions. The concept of a nitric oxide cycle has been expanded to include the NO-synthase and NO-synthase-independent component of its synthesis and the accompanying redox cascades in varying degrees of reversible reactions. The role of non-NO-synthase cycle components has been shown. Detailed characteristics of substrates for the synthesis of nitric oxide (NO) in the human body, which can be nitrogen oxides, nitrite and nitrate anions, and organic nitrates, as well as nitrates and nitrites of food products, are given. The importance of the human microbiota in the nitric oxide cycle has been shown. The role of significant components of nitrite and nitrate reductase systems in the nitric oxide cycle and the mechanisms of their activation and deactivation (participation of enzymes, cofactors, homeostatic indicators, etc.) under various conditions have been determined. Consideration of these factors allows for a detailed understanding of the mechanisms underlying pathological conditions of the respiratory system and the targeting of therapeutic agents. The complexity of the NO cycle with multidirectional cascades could be best understood using dynamic modeling.
dc.relation.ispartofseries Oxidative Medicine and Cellular Longevity
dc.title The State of the Nitric Oxide Cycle in Respiratory Tract Diseases
dc.type Review
dc.relation.ispartofseries-volume 2020
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS19420900-2020-2020-SID85095396405


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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