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Extracellular vesicles in the diagnosis and treatment of central nervous system diseases

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dc.contributor.author Shaimardanova A.
dc.contributor.author Solovyeva V.
dc.contributor.author Chulpanova D.
dc.contributor.author James V.
dc.contributor.author Kitaeva K.
dc.contributor.author Rizvanov A.
dc.date.accessioned 2021-02-25T06:40:12Z
dc.date.available 2021-02-25T06:40:12Z
dc.date.issued 2020
dc.identifier.issn 1673-5374
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160962
dc.description.abstract © The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the activity of the nervous system, participating in signal transmission between neurons and providing the interaction of central nervous system with all body systems. In many neurodegenerative diseases, neurons pack toxic substances into vesicles and release them into the extracellular space, which leads to the spread of misfolded neurotoxic proteins. The contents of neuron-derived extracellular vesicles may indicate pathological changes in the central nervous system, and the analysis of extracellular vesicle molecular content contributes to the development of non-invasive methods for the diagnosis of many central nervous system diseases. Extracellular vesicles of neuronal origin can be isolated from various biological fluids due to their ability to cross the blood-brain barrier. Today, the diagnostic potential of almost all toxic proteins involved in nervous system disease pathogenesis, specifically α-synuclein, tau protein, superoxide dismutase 1, FUS, leucine-rich repeat kinase 2, as well as some synaptic proteins, has been well evidenced. Special attention is paid to extracellular RNAs mostly associated with extracellular vesicles, which are important in the onset and development of many neurodegenerative diseases. Depending on parental cell type, extracellular vesicles may have different therapeutic properties, including neuroprotective, regenerative, and anti-inflammatory. Due to nano size, biosafety, ability to cross the blood-brain barrier, possibility of targeted delivery and the lack of an immune response, extracellular vesicles are a promising vehicle for the delivery of therapeutic substances for the treatment of neurodegenerative diseases and drug delivery to the brain. This review describes modern approaches of diagnosis and treatment of central nervous system diseases using extracellular vesicles.
dc.relation.ispartofseries Neural Regeneration Research
dc.subject biomarkers
dc.subject cell-mediated therapy
dc.subject central nervous system diseases
dc.subject diagnosis
dc.subject exosomes
dc.subject extracellular RNAs
dc.subject extracellular vesicles
dc.subject microRNAs
dc.subject microvesicles
dc.subject neurodegenerative diseases
dc.title Extracellular vesicles in the diagnosis and treatment of central nervous system diseases
dc.type Review
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 15
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 586
dc.source.id SCOPUS16735374-2020-15-4-SID85073799325


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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