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Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy

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dc.contributor.author Vong K.
dc.contributor.author Yamamoto T.
dc.contributor.author Tanaka K.
dc.date.accessioned 2021-02-25T06:40:10Z
dc.date.available 2021-02-25T06:40:10Z
dc.date.issued 2020
dc.identifier.issn 1613-6810
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160956
dc.description.abstract © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Akin to a cellular “fingerprint,” the glycocalyx is a glycan-enriched cellular coating that plays a crucial role in mediating cell-to-cell interactions. To gain a better understanding of the factors that govern in vivo recognition, artificial glycoproteins were initially created to probe changes made to the accumulation and biodistribution of specific glycan assemblies through biomimicry. As a result, the organ-specific accumulation for a variety of glycoproteins decorated with simple and/or complex glycans was identified. Additionally, binding trends with regard to cancer cell selectivity were also investigated. To exploit the knowledge gained from these studies, numerous groups thus became engaged in developing targeted drug methodologies based on the use of artificial glycoproteins. This has either been done through adopting the glycoprotein scaffold as a drug carrier, or to directly glycosylate therapeutic proteins/enzymes to localize their biological activity. The principle aim of this Review is to present the foundational research that has driven artificial glycoprotein-based targeting and subsequent adaptations with potential therapeutic applications.
dc.relation.ispartofseries Small
dc.subject artificial metalloenzymes
dc.subject cell recognition
dc.subject glycans
dc.subject glycoproteins
dc.subject targeted therapy
dc.title Artificial Glycoproteins as a Scaffold for Targeted Drug Therapy
dc.type Review
dc.relation.ispartofseries-issue 27
dc.relation.ispartofseries-volume 16
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS16136810-2020-16-27-SID85079709245


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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