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Extracellular Matrix in Neural Plasticity and Regeneration

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dc.contributor.author Chelyshev Y.A.
dc.contributor.author Kabdesh I.M.
dc.contributor.author Mukhamedshina Y.O.
dc.date.accessioned 2021-02-25T06:40:01Z
dc.date.available 2021-02-25T06:40:01Z
dc.date.issued 2020
dc.identifier.issn 0272-4340
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160941
dc.description.abstract © 2020, Springer Science+Business Media, LLC, part of Springer Nature. The extracellular matrix (ECM) is a fundamental component of biological tissues. The ECM in the central nervous system (CNS) is unique in both composition and function. Functions such as learning, memory, synaptogenesis, and plasticity are regulated by numerous ECM molecules. The neural ECM acts as a non-specific physical barrier that modulates neuronal plasticity and axon regeneration. There are two specialized types of ECM in the CNS, diffuse perisynaptic ECM and condensed ECM, which selectively surround the perikaryon and initial part of dendritic trees in subtypes of neurons, forming perineuronal nets. This review presents the current knowledge about the role of important neuronal ECM molecules in maintaining the basic functions of a neuron, including electrogenesis and the ability to form neural circuits. The review mainly focuses on the role of ECM components that participate in the control of key events such as cell survival, axonal growth, and synaptic remodeling. Particular attention is drawn to the numerous molecular partners of the main ECM components. These regulatory molecules are integrated into the cell membrane or disposed into the matrix itself in solid or soluble form. The interaction of the main matrix components with molecular partners seems essential in molecular mechanisms controlling neuronal functions. Special attention is paid to the chondroitin sulfate proteoglycan 4, type 1 transmembrane protein, neural-glial antigen 2 (NG2/CSPG4), whose cleaved extracellular domain is such a molecular partner that it not only acts directly on neural and vascular cells, but also exerts its influence indirectly by binding to resident ECM molecules.
dc.relation.ispartofseries Cellular and Molecular Neurobiology
dc.subject CSPGs
dc.subject HAPLN proteins
dc.subject Hyaluronan
dc.subject NG2
dc.subject Perineuronal nets
dc.subject Perisynaptic matrix
dc.subject Tenascins
dc.title Extracellular Matrix in Neural Plasticity and Regeneration
dc.type Review
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS02724340-2020-SID85094810766


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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