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GABA in developing rat skeletal muscle and motor neurons

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dc.contributor.author Sibgatullina G.V.
dc.contributor.author Malomouzh A.I.
dc.date.accessioned 2021-02-24T20:33:28Z
dc.date.available 2021-02-24T20:33:28Z
dc.date.issued 2020
dc.identifier.issn 0033-183X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160889
dc.description.abstract © 2020, Springer-Verlag GmbH Austria, part of Springer Nature. In recent years, considerable evidence is accumulated pointing to participation of gamma-aminobutyric acid (GABA) in intercellular signaling in the peripheral nervous system, including, in particular, neuromuscular transmission. However, where in the neuromuscular synapse GABA is synthesized remains not quite clear. We used histochemical methods to detect GABA and l-glutamate decarboxylase (GAD) in developing skeletal muscle fibers and in cultured motor neurons. We found that GABA can be detected already in myocytes, but with further muscle maturation, GABA synthesis gradually attenuates and completely ceases in early postnatal development. We found also that formation of GABA in muscle tissue does not depend on activity of GAD, but presumably proceeds through some other, alternative pathways. In motor neurons, GABA and GAD can be detected at the early stage of development (prior to synapse formation). Our data support the hypothesis that GABA and GAD, which are detectable in adult neuromuscular junctions, have neuronal origin. The mechanism of GABA production and its role in developing muscle tissue need further clarification.
dc.relation.ispartofseries Protoplasma
dc.subject GABA
dc.subject l-Glutamate decarboxylase
dc.subject Motor neuron
dc.subject Myocytes
dc.subject Neuromuscular junction
dc.subject Skeletal muscle fiber
dc.title GABA in developing rat skeletal muscle and motor neurons
dc.type Article
dc.relation.ispartofseries-issue 3
dc.relation.ispartofseries-volume 257
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1009
dc.source.id SCOPUS0033183X-2020-257-3-SID85078875681

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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