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Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution

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dc.contributor.author Golubev A.
dc.contributor.author Fatkhullin B.
dc.contributor.author Khusainov I.
dc.contributor.author Jenner L.
dc.contributor.author Gabdulkhakov A.
dc.contributor.author Validov S.
dc.contributor.author Yusupova G.
dc.contributor.author Yusupov M.
dc.contributor.author Usachev K.
dc.date.accessioned 2021-02-24T20:32:17Z
dc.date.available 2021-02-24T20:32:17Z
dc.date.issued 2020
dc.identifier.issn 0014-5793
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160765
dc.description.abstract © 2020 Federation of European Biochemical Societies Staphylococcus aureus is a bacterial pathogen and one of the leading causes of healthcare-acquired infections in the world. The growing antibiotic resistance of S. aureus obliges us to search for new drugs and treatments. As the majority of antibiotics target the ribosome, knowledge of its detailed structure is crucial for drug development. Here, we report the cryo-EM reconstruction at 3.2 Å resolution of the S. aureus ribosome with P-site tRNA, messenger RNA, and 10 RNA modification sites previously not assigned or visualized. The resulting model is the most precise and complete high-resolution structure to date of the S. aureus 70S ribosome with functional ligands.
dc.relation.ispartofseries FEBS Letters
dc.subject antibiotic resistance
dc.subject drug targets
dc.subject methyltransferases
dc.subject ribosome
dc.subject rRNA modifications
dc.subject Staphylococcus aureus
dc.title Cryo-EM structure of the ribosome functional complex of the human pathogen Staphylococcus aureus at 3.2 Å resolution
dc.type Article
dc.relation.ispartofseries-issue 21
dc.relation.ispartofseries-volume 594
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 3551
dc.source.id SCOPUS00145793-2020-594-21-SID85090767850


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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