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Comparison of cyclosporin variants B–E based on their structural properties and activity in mitochondrial membranes

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dc.contributor.author Efimov S.V.
dc.contributor.author Dubinin M.V.
dc.contributor.author Kobchikova P.P.
dc.contributor.author Zgadzay Y.O.
dc.contributor.author Khodov I.A.
dc.contributor.author Belosludtsev K.N.
dc.contributor.author Klochkov V.V.
dc.date.accessioned 2021-02-24T20:31:53Z
dc.date.available 2021-02-24T20:31:53Z
dc.date.issued 2020
dc.identifier.issn 0006-291X
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/160733
dc.description.abstract © 2020 Elsevier Inc. Cyclosporins B, C, D, and E were characterized by NMR spectroscopy, and backbone flexibility was studied by molecular dynamics simulation. Structures of the molecules were characterized by nuclear Overhauser effect spectroscopy, which revealed that the studied peptides have many common features. Molecular dynamics simulation showed that the backbone of cyclosporin E is relatively more rigid than in other peptides. Calcium-dependent swelling of liver mitochondria under the influence of four considered compounds was also investigated. Three of them were found to have the activity similar to cyclosporin A, inhibiting opening of the mitochondrial pore at concentrations within 100–300 nM. However, cyclosporin E did not show any biological effect at concentrations up to 1 μM. Results of this study agree with the idea on the correlation between the peptide chain flexibility and its bioavailability.
dc.relation.ispartofseries Biochemical and Biophysical Research Communications
dc.subject Cyclosporin
dc.subject Mitochondria
dc.subject Molecular dynamics
dc.subject NMR
dc.subject Pore
dc.title Comparison of cyclosporin variants B–E based on their structural properties and activity in mitochondrial membranes
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 526
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 1054
dc.source.id SCOPUS0006291X-2020-526-4-SID85083289169

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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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