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Selective Antimicrobial Effects of Curcumin@Halloysite Nanoformulation: A Caenorhabditis elegans Study

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dc.contributor.author Fakhrullina G.
dc.contributor.author Khakimova E.
dc.contributor.author Akhatova F.
dc.contributor.author Lazzara G.
dc.contributor.author Parisi F.
dc.contributor.author Fakhrullin R.
dc.date.accessioned 2020-01-22T20:42:21Z
dc.date.available 2020-01-22T20:42:21Z
dc.date.issued 2019
dc.identifier.issn 1944-8244
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/158011
dc.description.abstract © 2019 American Chemical Society. Alterations in the normal gastrointestinal microbial community caused by unhealthy diet, environmental factors, and antibiotic overuse may severely affect human health and well-being. Novel antimicrobial drug formulations targeting pathogenic microflora while not affecting or even supporting symbiotic microflora are urgently needed. Here we report fabrication of a novel antimicrobial nanocontainer based on halloysite nanotubes loaded with curcumin and protected with a dextrin outer layer (HNTs+Curc/DX) and its effective use to suppress the overgrowth of pathogenic bacteria in Caenorhabditis elegans nematodes. Nanocontainers have been obtained using vacuum-facilitated loading of hydrophobic curcumin into halloysite lumens. We have applied UV-vis and infrared spectroscopy, thermogravimetry and microscopy to characterize the HNTs+Curc/DX nanocontainers. In experiments in vitro we found that HNTs+Curc/DX effectively suppressed the growth of Serratia marcescens cells, whereas Escherichia coli bacteria were not affected. We applied HNTs+Curc/DX nanocontainers to alleviate the S. marcescens infection in C. elegans nematodes in vivo. The nematodes ingest HNTs+Curc/DX at 4-6 ng per worm, which results in improvement of the nematodes' fertility and life expectancy. Remarkably, treatment of S. marcescens-infected nematodes with HNTs+Curc/DX nanocontainers completely restored the longevity, demonstrating the enhanced bioavailability of hydrophobic curcumin. We believe that our results reported here open new avenues for fabrication of effective antimicrobial nanoformulations based on hydrophobic drugs and clay nanotubes.
dc.relation.ispartofseries ACS Applied Materials and Interfaces
dc.subject antimicrobial formulations
dc.subject Caenorhabditis elegans
dc.subject curcumin
dc.subject dark-field/hyperspectral microscopy
dc.subject drug delivery
dc.subject gut microbiota regulation
dc.subject halloysite
dc.subject nanocontainers
dc.title Selective Antimicrobial Effects of Curcumin@Halloysite Nanoformulation: A Caenorhabditis elegans Study
dc.type Article
dc.relation.ispartofseries-issue 26
dc.relation.ispartofseries-volume 11
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 23050
dc.source.id SCOPUS19448244-2019-11-26-SID85068144706


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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