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Cytokine storm combined with humoral immune response defect in fatal hemorrhagic fever with renal syndrome case, Tatarstan, Russia

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dc.contributor.author Garanina E.
dc.contributor.author Martynova E.
dc.contributor.author Davidyuk Y.
dc.contributor.author Kabwe E.
dc.contributor.author Ivanov K.
dc.contributor.author Titova A.
dc.contributor.author Markelova M.
dc.contributor.author Zhuravleva M.
dc.contributor.author Cherepnev G.
dc.contributor.author Shakirova V.
dc.contributor.author Khaertynova I.
dc.contributor.author Tarlinton R.
dc.contributor.author Rizvanov A.
dc.contributor.author Khaiboullina S.
dc.contributor.author Morzunov S.
dc.date.accessioned 2020-01-21T20:55:58Z
dc.date.available 2020-01-21T20:55:58Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157844
dc.description.abstract © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Hemorrhagic fever with renal syndrome (HFRS) is endemic in Tatarstan, where thousands of cases are registered annually. Puumala orthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. The pathogenesis of HFRS is still not well described, although the cytokine storm hypothesis is largely accepted. In this study, we present a comprehensive analysis of a fatal HFRS case compared with twenty four non-fatal cases where activation of the humoral and cellular immune responses, pro-inflammatory cytokines and disturbed blood coagulation were detected using immunological, histological, genetic and clinical approaches. Multiple organ failure combined with disseminated intravascular coagulation syndrome and acute renal failure was the cause of death. Decreased Interleukin (IL)-7 and increased IL-18, chemokine (C-C motif) ligand (CCL)-5, stem cell growth factor (SCGF)-b and tumor necrosis factor-beta (TNF-β) serum levels were found, supporting the cytokine storm hypothesis of hantavirus pathogenesis.
dc.subject CCL5
dc.subject Cytokine
dc.subject Fatal case
dc.subject HFRS
dc.subject IL-18
dc.subject Puumala orthohantavirus
dc.subject SCGF-b
dc.subject TNF-β
dc.title Cytokine storm combined with humoral immune response defect in fatal hemorrhagic fever with renal syndrome case, Tatarstan, Russia
dc.type Article
dc.relation.ispartofseries-issue 7
dc.relation.ispartofseries-volume 11
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2019-11-7-SID85068681229


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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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