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Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

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dc.contributor.author Gomzikova M.
dc.contributor.author James V.
dc.contributor.author Rizvanov A.
dc.date.accessioned 2020-01-21T20:55:50Z
dc.date.available 2020-01-21T20:55:50Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157842
dc.description.abstract © Copyright © 2019 Gomzikova, James and Rizvanov. The immunosuppressive potential of mesenchymal stem cells has been extensively investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and clinical studies have demonstrated that mesenchymal stem cells ameliorate immune-mediated disorders, including autoimmune diseases. However, to date mesenchymal stem cells have not become a widely used therapeutic agent due to safety challenges, high cost and difficulties in providing long term production. A key mechanism underpinning the immunomodulatory effect of MSCs is the production of paracrine factors including growth factors, cytokines, chemokines, and extracellular vesicles (EVs). MSCs derived EVs have become an attractive therapeutic agent for immunomodulation and treatment of immune-mediated disorders. In addition to many preclinical studies of MSCs derived EVs, their beneficial effects have been observed in patients with both acute graft-vs.-host disease and chronic kidney disease. In this review, we discuss the current findings in the field of MSCs derived EVs-based therapies in immune-mediated disorders and approaches to scale EV production for clinical use.
dc.subject autoimmune diseases
dc.subject extracellular vesicles
dc.subject graft-vs.-host disease
dc.subject immunosuppression
dc.subject microvesicles
dc.subject multiple sclerosis
dc.subject transplant rejection
dc.subject type 1 diabetes
dc.title Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation
dc.type Review
dc.relation.ispartofseries-volume 10
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2019-10-SID85076705291


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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