Kazan Federal University Digital Repository

The Pudovik reaction: the synthesis of bioactive α-aminophosphonates with long alkyl chains

Show simple item record

dc.contributor.author Galkina I.
dc.contributor.author Khayarov K.
dc.contributor.author Davletshin R.
dc.contributor.author Gaynullin A.
dc.contributor.author Gerasimov A.
dc.contributor.author Shulaeva M.
dc.contributor.author Pozdeev O.
dc.contributor.author Egorova S.
dc.contributor.author Usupova L.
dc.contributor.author Galkin V.
dc.date.accessioned 2020-01-21T20:45:57Z
dc.date.available 2020-01-21T20:45:57Z
dc.date.issued 2019
dc.identifier.issn 1042-6507
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157747
dc.description.abstract © 2019, © 2019 Taylor & Francis Group, LLC. In this research we investigated the reactions of substituted naphthaldehyde with amines. The condensation of do-, tetra-, hexa-, octadecan-1-amines with 2-hydroxy-1-naphthaldehyde yielded a series of azomethines in good yields. Subsequent reaction of these compounds with didodecylphosphine oxide yielded α-aminophosphonates. The in vitro microbiological activity of the synthesized phosphorus compounds against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG/DSC).
dc.relation.ispartofseries Phosphorus, Sulfur and Silicon and the Related Elements
dc.subject antimicrobial activity
dc.subject long alkyl chains
dc.subject α-aminophosphonates
dc.title The Pudovik reaction: the synthesis of bioactive α-aminophosphonates with long alkyl chains
dc.type Article
dc.relation.ispartofseries-issue 4-6
dc.relation.ispartofseries-volume 194
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 463
dc.source.id SCOPUS10426507-2019-194-46-SID85060608188

Files in this item

This item appears in the following Collection(s)

  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

Show simple item record

Search DSpace

Advanced Search


My Account