dc.contributor.author |
Khabibrakhmanov I. |
|
dc.contributor.author |
Ziyatdinova N. |
|
dc.contributor.author |
Khisamieva L. |
|
dc.contributor.author |
Biktemirova R. |
|
dc.contributor.author |
Zefirov T. |
|
dc.date.accessioned |
2020-01-21T20:40:44Z |
|
dc.date.available |
2020-01-21T20:40:44Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
0972-5210 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/157606 |
|
dc.description.abstract |
© 2019 Plant Archives. All rights reserved. The study was conducted on outbred newborn 6-7 day old rats. To stimulate alpha1A-adrenergic receptors, the pharmacological preparation A-61603 was used in concentrations of 10-9 - 10-6 mol. They studied the reaction of contraction force of isolated atrial and ventricular myocardial strips of the heart in response to the action of a selective agonist. Stimulation of alpha1Aadrenergic receptors depending on the concentration of agonist A-61603 caused multidirectional inotropic effects. A-61603 at concentrations of 10-9 and 10-8 mol leads to the decrease, and at the concentrations of 10-7 and 10-6 mol, to the increase of the atrial myocardial strips and ventricle contraction strength among newborn rat. In addition, the duration of a positive inotropic effect also depends on the concentration of the agonist. Our previous studies have shown that in the ventricular myocardium of adult rats, A-61603 in the concentration range of 10-9 - 10-6 mol causes only a negative inotropic effect. It should be noted that the nature of the inotropic effects of alpha1A-adrenergic receptors may depend not only on the activity of different signaling pathways triggered by both different subtypes and a separate subtype of receptors, but may also be associated with the features of activation and maturity of individual elements of one signaling system at different stages of postnatal ontogenesis. |
|
dc.relation.ispartofseries |
Plant Archives |
|
dc.subject |
-adrenergic receptors -adrenergic receptors. 1A |
|
dc.subject |
: Rat |
|
dc.subject |
A-61603 |
|
dc.subject |
Heart |
|
dc.subject |
Inotropy |
|
dc.subject |
Myocardium |
|
dc.title |
Alpha(1a)-adrenoreceptor participation in myocardial contractility regulation among newborn rats |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
2 |
|
dc.relation.ispartofseries-volume |
19 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
2188 |
|
dc.source.id |
SCOPUS09725210-2019-19-2-SID85074994934 |
|