dc.contributor.author |
Mostovaya O. |
|
dc.contributor.author |
Valiullina Y. |
|
dc.contributor.author |
Chan C. |
|
dc.contributor.author |
Potrekeeva O. |
|
dc.contributor.author |
Padnya P. |
|
dc.contributor.author |
Zuev Y. |
|
dc.contributor.author |
Stoikov I. |
|
dc.date.accessioned |
2020-01-21T20:40:36Z |
|
dc.date.available |
2020-01-21T20:40:36Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
0959-9436 |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/157589 |
|
dc.description.abstract |
© 2019 A p-tert-butylthiacalix[4]arene derivative containing tryptophan moieties on the lower rim was synthesized and proposed as a chymotrypsin inhibitor. Its ability to competitively inhibit the enzyme was revealed by kinetic methods. A mechanism of the inhibitory action has been established, which consists in the binding of macrocycle tryptophan moieties to the enzyme active site, resulting in its blocking. |
|
dc.relation.ispartofseries |
Mendeleev Communications |
|
dc.title |
Synthetic modulator of chymotrypsin activity based on p-tert-butylthiacalix[4]arene |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
5 |
|
dc.relation.ispartofseries-volume |
29 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
520 |
|
dc.source.id |
SCOPUS09599436-2019-29-5-SID85073758874 |
|