dc.contributor.author |
Mirgayazova R. |
|
dc.contributor.author |
Khadiullina R. |
|
dc.contributor.author |
Mingaleeva R. |
|
dc.contributor.author |
Chasov V. |
|
dc.contributor.author |
Gomzikova M. |
|
dc.contributor.author |
Garanina E. |
|
dc.contributor.author |
Rizvanov A. |
|
dc.contributor.author |
Bulatov E. |
|
dc.date.accessioned |
2020-01-15T22:13:32Z |
|
dc.date.available |
2020-01-15T22:13:32Z |
|
dc.date.issued |
2019 |
|
dc.identifier.issn |
2322-181X |
|
dc.identifier.uri |
https://dspace.kpfu.ru/xmlui/handle/net/157170 |
|
dc.description.abstract |
© 2019 Shiraz University. Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. Furthermore, putative p53-mediated mechanism of action of this compound is supported by quantitative analysis of TP53, MDM2 and PUMA genes expression, as well as luciferase-based p53 pathway activation assay. Multiplex immunoassay analysis of inflammatory markers revealed potential modulation of several cytokines and chemokines. |
|
dc.relation.ispartofseries |
Molecular Biology Research Communications |
|
dc.subject |
Isatin-Schiff base |
|
dc.subject |
Metal complex |
|
dc.subject |
P53 |
|
dc.subject |
Transcriptional activity |
|
dc.subject |
Tumor cells |
|
dc.title |
Novel Isatin-based activator of p53 transcriptional functions in tumor cells |
|
dc.type |
Article |
|
dc.relation.ispartofseries-issue |
3 |
|
dc.relation.ispartofseries-volume |
8 |
|
dc.collection |
Публикации сотрудников КФУ |
|
dc.relation.startpage |
119 |
|
dc.source.id |
SCOPUS2322181X-2019-8-3-SID85072914857 |
|