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dc.contributor.author | Mirgayazova R. | |
dc.contributor.author | Khadiullina R. | |
dc.contributor.author | Mingaleeva R. | |
dc.contributor.author | Chasov V. | |
dc.contributor.author | Gomzikova M. | |
dc.contributor.author | Garanina E. | |
dc.contributor.author | Rizvanov A. | |
dc.contributor.author | Bulatov E. | |
dc.date.accessioned | 2020-01-15T22:13:32Z | |
dc.date.available | 2020-01-15T22:13:32Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 2322-181X | |
dc.identifier.uri | https://dspace.kpfu.ru/xmlui/handle/net/157170 | |
dc.description.abstract | © 2019 Shiraz University. Bioinorganic medicinal chemistry remains a hot field for research aimed at developing novel anti-cancer treatments. Discovery of metal complexes as potent antitumor chemotherapeutics such as cisplatin led to a significant shift of focus toward organometallic/ bioinorganic compounds containing transition metals and their chelates as novel scaffolds for drug discovery. In that way, transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. Here, we report novel data on p53 activating Isatin-based Cu(II) complex exhibiting cytotoxic properties towards HCT116 and MCF7 tumor cell lines, as confirmed by cell viability assay and flow cytometry analysis of apoptosis. Furthermore, putative p53-mediated mechanism of action of this compound is supported by quantitative analysis of TP53, MDM2 and PUMA genes expression, as well as luciferase-based p53 pathway activation assay. Multiplex immunoassay analysis of inflammatory markers revealed potential modulation of several cytokines and chemokines. | |
dc.relation.ispartofseries | Molecular Biology Research Communications | |
dc.subject | Isatin-Schiff base | |
dc.subject | Metal complex | |
dc.subject | P53 | |
dc.subject | Transcriptional activity | |
dc.subject | Tumor cells | |
dc.title | Novel Isatin-based activator of p53 transcriptional functions in tumor cells | |
dc.type | Article | |
dc.relation.ispartofseries-issue | 3 | |
dc.relation.ispartofseries-volume | 8 | |
dc.collection | Публикации сотрудников КФУ | |
dc.relation.startpage | 119 | |
dc.source.id | SCOPUS2322181X-2019-8-3-SID85072914857 |