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Novel Solid Dispersions Increasing the Solubility of Prothionamide

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dc.contributor.author Krasnyuk I.
dc.contributor.author Beliatskaya A.
dc.contributor.author Stepanova O.
dc.contributor.author Galkina I.
dc.contributor.author Lutsenko S.
dc.contributor.author Litvinova T.
dc.date.accessioned 2020-01-15T22:12:59Z
dc.date.available 2020-01-15T22:12:59Z
dc.date.issued 2019
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157102
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. Water solubility of prothionamide and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied. The most promising results were obtained with the solid dispersion with polyvinylpyrrolidone, which provided a 2.6-fold general increase of drug’s solubility and about a 6-fold dissolution rate increase, the maximal values among the studied drug forms. The results of complex physicochemical studies suggested that the improved drug release was due to micronization and solubilizing action of the polymer. A principal factor was the destruction of the crystal lattice and formation of amorphous particles in the solid dispersion. The obtained data can be useful for the development of modified pharmaceutical forms of prothionamide with improved drug release profile.
dc.relation.ispartofseries BioNanoScience
dc.subject Polyethyleneglycol-1500 (PEG)
dc.subject Polyvinylpyrrolidone-10000 (PVP)
dc.subject Prothionamide
dc.subject Solid dispersions
dc.subject Solubility
dc.subject β-Cyclodextrin
dc.title Novel Solid Dispersions Increasing the Solubility of Prothionamide
dc.type Article
dc.relation.ispartofseries-issue 4
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 833
dc.source.id SCOPUS21911630-2019-9-4-SID85070316842


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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