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Analysis of the Interaction and Proliferative Activity of Adenocarcinoma, Peripheral Blood Mononuclear and Mesenchymal Stromal Cells after Co-Cultivation In Vitro

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dc.contributor.author Kitaeva K.
dc.contributor.author Prudnikov T.
dc.contributor.author Gomzikova M.
dc.contributor.author Kletukhina S.
dc.contributor.author James V.
dc.contributor.author Rizvanov A.
dc.contributor.author Solovyeva V.
dc.date.accessioned 2020-01-15T22:12:55Z
dc.date.available 2020-01-15T22:12:55Z
dc.date.issued 2019
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157094
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The tumor microenvironment is a heterogeneous population of cells actively involved in the process of growth and development of a tumor. Research has demonstrated the interactions between the different populations of cells are critical for the formation of the tumor microenvironment and, if recapitulated experimentally, can be used to produce more effective models for preclinical screening of anticancer drugs. In this study, we demonstrate co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes in the proliferative activity of the peripheral blood mononuclear cells and mesenchymal stromal cell populations. This data supports the further development of in vitro co-culture systems utilizing these cell types for pre-clinical screening of anticancer drugs.
dc.relation.ispartofseries BioNanoScience
dc.subject Adenocarcinoma
dc.subject Co-culture
dc.subject Drug screening
dc.subject Intercellular interaction
dc.subject Mesenchymal stromal cell
dc.subject Mononuclear blood cell
dc.subject Test system
dc.title Analysis of the Interaction and Proliferative Activity of Adenocarcinoma, Peripheral Blood Mononuclear and Mesenchymal Stromal Cells after Co-Cultivation In Vitro
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 502
dc.source.id SCOPUS21911630-2019-9-2-SID85071745017


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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