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Screening Assessment of Renal Function Status in Healthy Smoking Volunteers

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dc.contributor.author Abdulkhakov S.
dc.contributor.author Arkhipov E.
dc.contributor.author Faizullin R.
dc.contributor.author Sidorova I.
dc.contributor.author Ibragimova A.
dc.contributor.author Gaysina L.
dc.contributor.author Oslopova J.
dc.contributor.author Pronina E.
dc.contributor.author Safina D.
dc.contributor.author Valeeva I.
dc.contributor.author Salomatin V.
dc.contributor.author Gnuchikh E.
dc.contributor.author Arinina E.
dc.contributor.author Kiassov A.
dc.date.accessioned 2020-01-15T22:12:52Z
dc.date.available 2020-01-15T22:12:52Z
dc.date.issued 2019
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157089
dc.description.abstract © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The study objective was to evaluate the renal function status in overall healthy smokers. Renal function status was studied in 61 apparently healthy smokers aged 21–64 years (49 males and 12 females). The evaluation included taking a history with the smoking status assessment, a physical examination with assessment of systolic and diastolic blood pressure, blood and urine biochemistry, and calculation of glomerular filtration rate (GFR; CKD-EPI, 2009). The period of observation lasted for 7 days. High blood pressure and obesity had no impact on the kidney function (p > 0.05). Healthy smoking volunteers initially had a high GFR and a “high-normal” urine albumin level as compared to the group of healthy non-smokers (р = 0.000 and р = 0.012, respectively). The risk analysis showed that smoking increased 11-fold the risk of hyperfiltration (RR = 11.1, CI 95% 1.57–76.51, p = 0.001) and 5-fold the occurrence of albuminuria (RR = 5.1, CI 95% 0.71–36.99, p = 0.009) in smokers without initial renal pathology as compared to never-smokers. Those who abstained from smoking showed a moderate decrease of albuminuria (p = 0.049). Systematic tobacco consumption contributes to the development of a renal dysfunction with the occurrence of albuminuria and hyperfiltration (GFR ≥ 125 ml/min/1.73 m2). Timely smoking cessation promotes the regression of albuminuria.
dc.relation.ispartofseries BioNanoScience
dc.subject Albuminuria
dc.subject Kidney
dc.subject Renal function
dc.subject Smoking
dc.title Screening Assessment of Renal Function Status in Healthy Smoking Volunteers
dc.type Article
dc.relation.ispartofseries-issue 2
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 510
dc.source.id SCOPUS21911630-2019-9-2-SID85065980893


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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