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Pyrimidine Derivative Ameliorates Spinal Cord Injury via Anti-apoptotic, Anti-inflammatory, and Antioxidant Effects and by Regulating Rho GTPases

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dc.contributor.author Povysheva T.
dc.contributor.author Sabirova S.
dc.contributor.author Shashin M.
dc.contributor.author Galyametdinova I.
dc.contributor.author Semenov V.
dc.contributor.author Chelyshev Y.
dc.date.accessioned 2020-01-15T22:12:49Z
dc.date.available 2020-01-15T22:12:49Z
dc.date.issued 2019
dc.identifier.issn 2191-1630
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/157081
dc.description.abstract © 2018, Springer Science+Business Media, LLC, part of Springer Nature. One of the most important strategies for the treatment of spinal cord injury is searching for new and effective pharmacological neuroprotectors and regeneration stimulators. The derivatives of pyrimidine are universal stimulators of the regeneration of various tissues as they support the recovery of nervous structures. The protective effect of the cocrystal of 1,2-dihydro-4,6-dimethyl-1-(2-hydroxyethyl)-pyrimidinone-2 with para-aminobenzoic acid (compound conjugate III, CCIII) was explored on a rat model with a contusion spinal cord injury. Injection of CCIII significantly reduced the expression of tumor necrosis factor α (TNF-α), inhibited the synthesis of myeloperoxidase (MPO), matrix metalloproteinase 9 (MPP9), cyclooxygenase-2 (COX2), and macrophage marker CD68, and increased the level of superoxide dismutase 1 (SOD1). Additionally, the expression of caspase-7 markers in the damaged tissue decreased under the action of CCIII. Treatment with the CCIII maintained a population of Olig2-positive myelin-forming cells at 30 days post-injury. The detected therapeutic effect is comparable with that of riluzole.
dc.relation.ispartofseries BioNanoScience
dc.subject Antiinflammatory drugs
dc.subject Pyrimidine derivative
dc.subject Rho GTPases
dc.subject Riluzole
dc.subject SOD1
dc.subject Spinal cord injury
dc.subject TNF-α
dc.title Pyrimidine Derivative Ameliorates Spinal Cord Injury via Anti-apoptotic, Anti-inflammatory, and Antioxidant Effects and by Regulating Rho GTPases
dc.type Article
dc.relation.ispartofseries-issue 1
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.relation.startpage 224
dc.source.id SCOPUS21911630-2019-9-1-SID85064015773


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  • Публикации сотрудников КФУ Scopus [24551]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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