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Metadherin: A therapeutic target in multiple cancers

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dc.contributor.author Dhiman G.
dc.contributor.author Srivastava N.
dc.contributor.author Goyal M.
dc.contributor.author Rakha E.
dc.contributor.author Lothion-Roy J.
dc.contributor.author Mongan N.
dc.contributor.author Miftakhova R.
dc.contributor.author Khaiboullina S.
dc.contributor.author Rizvanov A.
dc.contributor.author Baranwal M.
dc.date.accessioned 2020-01-15T22:11:10Z
dc.date.available 2020-01-15T22:11:10Z
dc.date.issued 2019
dc.identifier.uri https://dspace.kpfu.ru/xmlui/handle/net/156923
dc.description.abstract Copyright © 2019 Dhiman, Srivastava, Goyal, Rakha, Lothion-Roy, Mongan, Miftakhova, Khaiboullina, Rizvanov and Baranwal. Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in nonmalignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.
dc.subject Cancer
dc.subject Chemoresistance
dc.subject Immunotherapy
dc.subject Metadherin
dc.subject MicroRNA
dc.title Metadherin: A therapeutic target in multiple cancers
dc.type Review
dc.relation.ispartofseries-issue MAY
dc.relation.ispartofseries-volume 9
dc.collection Публикации сотрудников КФУ
dc.source.id SCOPUS-2019-9--SID85067653198

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  • Публикации сотрудников КФУ Scopus [22633]
    Коллекция содержит публикации сотрудников Казанского федерального (до 2010 года Казанского государственного) университета, проиндексированные в БД Scopus, начиная с 1970г.

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